Narcolepsy is a disorder caused by losing orexin neurons, marked by excessive daytime sleepiness and cataplexy, and sudden weakening of muscle control. Previously, we found two kinds of neurons ...

Cataplexy is a sudden, brief loss of voluntary muscle tone triggered by strong emotions such as laughter, excitement, anger or fear. There is a strong association between cataplexy and narcolepsy, a ...

Cataplexy is a sudden episode of muscle weakness that occurs while fully aware and conscious. It can be triggered by emotional events, such as laughing, crying or fear, and is usually transient in ...

Narcolepsy, with or without cataplexy, can have a substantial detrimental effect on well-being and quality of life. Because there is no cure for this condition, current treatments aim to improve ...

Gelastic cataplexy is a sudden loss of muscle tone without loss of consciousness triggered by laughter. It’s a characteristic sign of a rare genetic disease called Niemann Pick disease type C.

SAN DIEGO — The investigational drug AXS-12 (reboxetine, Axsome Therapeutics) is safe and effective for the treatment of cataplexy (emotionally induced muscle weakness) and excessive daytime ...

And not figuratively, either. Sometimes people have found that certain emotions literally cause their muscles to unhook from their brains. They collapse entirely. This is not some strange disease, or ...

Cataplexy refers to episodes of muscle weakness that typically occur with narcolepsy type one — roughly 75% of people with this sleep disorder experience cataplexy. But among the general population, ...

SAN DIEGO -- AXS-12 (reboxetine), an investigational treatment for narcolepsy, reduced weekly cataplexy attacks and in some cases provided complete remission, the phase III SYMPHONY study showed. From ...