RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions ...

Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to ...

The preprint also presented a workflow for “generative epigenomics,” which designed DNA sequences with desirable chromatin accessibility profiles to simulate eukaryotic gene regulation.

This review, led by Prof. Bochen Jiang at the School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, provides a comprehensive ...

Eukaryotic gene regulation typically involves these many diverse regulatory blocks of DNA, along with one or more transcription factors and other molecules, all gathering around a gene like a ...

Timothy Frei, Ching-Hsiang Chang, Maurice Filo, Asterios Arampatzis, Mustafa Khammash, A genetic mammalian proportional–integral feedback control circuit for robust and precise gene regulation, ...

Origin-recognition complex (ORC) plays an unexpectedly broad role in the regulation of human cell gene expression, according ...

Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports . This is the first detailed ...

In eukaryotes, the tight or loose packaging of the genes in chromatin (DNA plus specific proteins) can control whether the genes can be expressed to form their encoded product. Chromatin is ...

Eukaryotic gene regulation as a field has matured much during decades of study, but understanding it on a genome-wide basis has started in earnest only with the assembly of genomic data.