Wnt signalling comprises a network of pathways essential to embryonic development, tissue patterning and stem cell maintenance. The canonical branch centres on the stabilization of β-catenin, which ...

Tumor cells in colorectal cancer exploit an important signaling pathway that normally controls embryo development. Researchers have now shown how a protein that controls the development of the arms ...

Plants deploy sugars not only as essential carbon and energy sources but also as critical signalling molecules that orchestrate developmental programmes. Specific sensor–transducer proteins, including ...

Targeting the WNT signaling pathway represents a promising strategy for cancer therapy. The field has evolved to include numerous inhibitors currently under preclinical and clinical investigation.

What parents experience before conception and during pregnancy can leave a lasting impact on offspring brain development.

The heart and brain are among the earliest and most metabolically demanding organs in human development. Though historically studied in isolation, both ...

LMU researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor development in skin cancer. A team led by LMU pharmacologist Professor Christian ...

Peptide research has expanded dramatically as investigators continue to explore short amino acid chains that participate in intricate regulatory networks across biological system. Among these ...

A study led by a University of Louisville School of Medicine pediatrics and child neurology researcher reveals how a specific signaling mechanism in microglia, the brain immune cell, can regulate ...

Researchers at Tulane University, with a team of colleagues from eight other universities, have discovered a new nerve cell signaling mechanism that could transform our understanding of pain and lead ...