Scientists have elucidated the first steps of transcription-coupled repair (TCR), a critical but still mysterious mechanism of DNA repair. When genetic information is being transcribed from DNA to ...

During transcription, the first step in gene expression, RNAPs "read" DNA sequences and assemble messenger RNA (mRNA), which in turn serves as the template for the proteins necessary for life.

DNA’s chemical cousin, RNA, was the messenger that carries DNA instructions from the double helix in the cell’s nucleus to ...

The findings, captured within 500 milliseconds of RNAP mixing with DNA, shed light on fundamental mechanisms of transcription, and answer long-standing questions about the initiation mechanism and ...

How chromatin responds to transcription-blocking DNA lesions is unclear. This study reveals that RNA polymerase II (RNAPII) ...

A detailed picture of what happens when DNA transcription is paused early in the process has been obtained by structural ...

A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription into RNA – the first step of the process by which an organism ...

By clarifying how the DNA sequence affects transcription accuracy, the study offers a new perspective on its fidelity, suggesting that errors are not in random locations but are instead influenced ...