How chromatin responds to transcription-blocking DNA lesions is unclear. This study reveals that RNA polymerase II (RNAPII) ...

In addition to BRCA1’s role in repairing DNA damage and preventing it from accumulating across the genome, the study indicates this invaluable protein appears to improve transcription fidelity.

Aug 12, 2025 Pressing pause on DNA transcription What happens on the atomic scale when DNA transcription is paused has been unveiled for the first time. (Nanowerk News) A detailed picture of what ...

DNA’s chemical cousin, RNA, was the messenger that carries DNA instructions from the double helix in the cell’s nucleus to ...

In 1957, just four years after Francis Crick and other scientists solved the riddle of DNA’s structure—the now famous double ...

DNA has to be carefully organized and packaged so it will fit into the nucleus of cells; compacted DNA that's been organized with other proteins is known as chromatin. The structure of the genome can ...

Penn State. "New mechanism for terminating transcription of DNA into RNA in bacteria." ScienceDaily. ScienceDaily, 8 May 2021. <www.sciencedaily.com / releases / 2021 / 05 / 210507160000.htm>.

DNA damage is prevented by Chi sites which cause RecBCD pausing and subsequent loading of RecA onto the 3’ssDNA. RNAP mediated transcription and RecBCD resection co‐occur on the DNA template.

These are the DNA-binding protein mitochondrial transcription factor A (TFAM) and mitochondrial transcription factor B2 (TFB2M). TFB2M is a gene duplication product which controls local ‘melting ...

Eight residues in the 29 residue basic DNA binding domain were mutated to create a `CEBP DNA binding domain'. This mutated domain was cloned into the context of v-Jun to create VJCEBP.