Citation: Adams, J. (2008) DNA sequencing technologies. Nature Education 1 (1):193 The Human Genome project set out to sequence all of the 3 billion nucleotides in the human genome.

Emboldened by the success of next-generation sequencing, scientists are pursuing the holy grail of genomics—the '$1,000 genome'—with single-molecule approaches. Nathan Blow reports.

DNA Methylation Market OverviewDNA methylation is a biological process in which methyl groups (CH3) are added to the DNA ...

More information: June H. Tan et al, Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing, Nature Biotechnology (2025). DOI: 10.1038/s41587-025-02554-7 ...

More information: Arjun S. Nanda et al, Direct transposition of native DNA for sensitive multimodal single-molecule sequencing, Nature Genetics (2024). DOI: 10.1038/s41588-024-01748-0 ...

After treatment with sodium bisulfite, unmethylated cytosine residues become uracil residues, which are recognized as thymine after PCR amplification and sequencing analysis. Researchers determine ...

Despite the great progress in recent years, the current DNA sequencing methods, typically based on fluorescent labelling, are still time-consuming and relatively expensive techniques, which have ...

Burrows says most DNA sequencing methods reveal mutations because the methods read the bases A, C, G and T. When sequencing reveals one of those bases out of place, that is a mutation.