Developing a method that can quickly and easily generate replication-defective live-attenuated viruses, the researchers said, will accelerate vaccine development for diseases caused by DNA viruses.

Researchers at San Diego State University and Michigan State University are shedding new light on how viruses meticulously ...

In contrast, when a virus hijacks a host cell's DNA replication machinery, it replicates hundreds of times. This "unlicensed" replication is not subject to the same quality control and is much ...

A common hallmark of viral genome replication is a high mutation rate, which can aid in their ability to evade new treatments and acquire resistance to once-effective antiviral medications.

In contrast, when a virus hijacks a host cell's DNA replication machinery, it replicates hundreds of times. This "unlicensed" replication is not subject to the same quality control and is much ...

This was supposed to give the virus access to the replication machinery it needed. This would mean that TAg would have to be expressed before cells began replicating their DNA.

A rare genetic mutation that makes some people naturally impervious to viral diseases could lead to a universal antiviral ...

The monkeypox virus has its own DNA polymerase F8 which, when together with the processive cofactors A22 and E4, constitutes the polymerase holoenzyme for genome replication.

Instead of relying on the cell's repair mechanisms, the vaccinia virus MacGyvers a tool for DNA repair from one that it already uses to copy DNA, reports a team of researchers at the Medical ...

The cold sore-causing Herpes Simplex Virus (HSV-1) hijacks human cells and reconfigures its DNA within just an hour after infection, according to a new study that may help tackle the pathogen.

To better understand BKPyV replication and ways to prevent it, researchers in the UAB Department of Microbiology have published a single-cell analysis of BKPyV infection in primary kidney cells. Their ...