When the fork stalls, the replication checkpoint steps in and identifies the problems with the DNA. This checkpoint activates a signal transduction cascade to arrest the cell cycle and coordinate ...

DNA replication occurs during the S phase of cell division. In E. coli, this means that the entire genome is replicated in just 40 minutes, at a pace of approximately 1,000 nucleotides per second.

Part of the DNA replication process -- in humans and in other life forms -- involves loading of molecular structures called sliding clamps onto DNA. This crucial step in DNA replication had remained ...

Key step in molecular 'dance' that duplicates DNA deciphered Date: July 14, 2013 Source: Brookhaven National Laboratory Summary: Scientists have captured new details of the biochemical ...

More information: Bruce Stillman et al, Mechanisms for licensing origins of DNA replication in eukaryotic cells, Nature Structural & Molecular Biology (2025). DOI: 10.1038/s41594-025-01587-5 ...

Scientists have discovered that a protein known as Cdt1, which is required for DNA replication, also plays an important role in a later step of the cell cycle, mitosis. The finding presents a ...

The human genome consists of 3 billion base pairs, and when a cell divides, it takes about seven hours to complete making a copy of its DNA. That's almost 120,000 base pairs per second. At that ...