Unexpected slowdowns or spikes in this signal were often interpreted as knots in DNA. But now, a new study published Aug. 12 ...

Adenine in DNA Replication During DNA replication, the double helix unwinds, and each strand serves as a template for synthesizing a new complementary strand. Adenine on the template strand will ...

How chromatin responds to transcription-blocking DNA lesions is unclear. This study reveals that RNA polymerase II (RNAPII) ...

Junqiu Zhang, Xin Zhao, Lu Liu, Hao-Dong Li, Liya Gu, Diego H. Castrillon, Guo-Min Li, The mismatch recognition protein MutSα promotes nascent strand degradation at stalled replication forks, ...

By creating a more true-to-life representation of DNA's environment, researchers have discovered that strand separation may take more mechanical force than the field previously believed.

Certain forms of DNA damage are associated with so-called R-loops. These are three-stranded structures consisting of two DNA strands and one RNA strand, whereby one of the DNA strands forms the loop.

By creating a more true-to-life representation of DNA's environment, researchers at Northwestern University have discovered that strand separation - the essential process a "resting" double helix ...

The manipulation of DNA replication and the adoption of advanced gene-editing technologies illustrate a remarkable convergence of scientific innovation and ethical considerations.

Recent efforts in our lab have focused on complexes mediating DNA double strand break (DSB) repair. These range from the Structure Maintenance of Chromosome Smc5/6 complex involved in rescue of ...