A new study shows that the DNA repair enzyme Polβ plays a vital role in protecting the developing brain from harmful ...

5 latest biotechnology breakthroughs, from genome sequencing to microbiome manipulation, revolutionizing medicine, ...

But 5hmC is not just a transient step in the DNA demethylation pathway but represents an important epigenetic modification in its own right. 5hmC is a key component of the 6-base genome with an ...

A research group led by the University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations. The study found that a ...

But there are lots of additional ways to modify nucleic acids that might be useful. And it’s an open question as to whether enzymes that perform additional modifications have evolved. So, some ...

A long search beyond the realm of microbes N4-methylcytosine (4mC) is a form of immunity in bacteria, camouflaging their genome from enzymes that degrade foreign sequences by adding a methyl ...

Center for Genomic Regulation. "DNA damage repaired by antioxidant enzymes." ScienceDaily. ScienceDaily, 5 June 2023. <www.sciencedaily.com / releases / 2023 / 06 / 230601160139.htm>.

While 4mC and 5mC are chemical modifications of the cytosine nucleotide -- one of the building blocks of DNA -- 6mA is the only one to target the adenine nucleotide.

Antioxidant enzymes are deployed to mop up reactive oxygen species at their source before they reach DNA, a defensive strategy that protects the roughly 3 billion nucleotides from suffering ...

Enzymes that cut DNA at specific sites are called endonucleases; these enzymes play many roles in genomic replication, fidelity, and defense. The initial discovery of restriction endonucleases in the ...