The discovery of Hoogsteen base pairs, an alternative pairing mode to the canonical Watson–Crick structure, has significantly broadened our understanding of DNA dynamics. This conformation, in ...

The specific base-pairing interactions between nucleobases are the foundation of the storage and transmission of genetic information. In DNA, adenine always pairs with thymine (A-T), and guanine ...

The cells of all organisms contain genetic information in their DNA as a two-base-pair sequence made up of four molecules – A, T, C, G (Adenine, Cytosine, Thymine, and Guanine).

Most of the time, DNA replication in the body goes smoothly, with nucleotides locking arms with their complementary base pair and marching through the cycle together in intended A-T and C-G fashion.

Hybridization refers to the spontaneous binding of two complementary strands through base pair matching.

Beam is pursuing the application of base editing, its proprietary CRISPR-based technology that can make precise edits to single base pairs in DNA and RNA.

Likewise, editing of DNA that relies on base-pair modification instead of double-stranded cuts gets around some of those other limitations.

The Cas9 protein forms a complex with the single guide RNA and causes site-specific DSBs via the RNA-DNA complementary base pairing. Therapies for HBV ...

Hoogsteen base pairing: An alternative configuration to Watson–Crick pairing in DNA, involving a 180° rotation of the purine base that results in unique hydrogen bonding and structural orientation.