Two studies show how a small change in FAN1, a DNA repair protein, can speed up HD. The alteration disrupts FAN1’s DNA grip, ...

Metabolic dysfunction-associated steatotic liver disease (MASLD), including metabolic dysfunction-associated steatohepatitis (MASH), is the most common aetiology of liver disease worldwide. MASLD is ...

A new article in the peer-reviewed journal Nucleic Acid Therapeutics describes the characterization of antibodies targeting antisense oligonucleotide (ASO) phosphorothioate and 2&rsquo ...

AMX0114 is an investigational antisense oligonucleotide targeting calpain-2 (CAPN2), a calcium-activated protease believed to play a role in ALS disease progression.

Secarna Pharmaceuticals GmbH & Co. KG (Secarna), a leading independent European antisense drug discovery and development company, and Orbit Discovery Ltd. (Orbit), a leader in the discovery of ...

RNA (ribonucleic acid) plays a central role in the translation of DNA information into proteins. There are different types of RNA, one of which is known as messenger RNA (mRNA).