Small cell lung cancer (SCLC) is one of the most aggressive forms of lung cancer, with a five-year survival rate of only five percent. Despite this poor prognosis, SCLC is initially highly responsive ...

Figure 1: CYLD is essential for necrosis. Figure 2: CYLD is a substrate for proteolysis by caspase 8. Figure 4: CYLD D215A triggers programmed necrosis in the absence of caspase inhibitors. Figure 5: ...

Small cell lung cancer (SCLC) is one of the most aggressive forms of lung cancer, with a five-year survival rate of only 5%.

Caspase-8 is frequently deficient in several kinds of human tumors, suggesting that certain effects of this enzyme restrict tumor development. To examine the nature of the cellular function whose ...

Bei kleinzelligem Lungenkrebs beginnt die Aggressivität oft bereits vor der Diagnose, da eine stille Entzündung im ...

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows. In order to safeguard ...

Wissenschaftler*innen der Universität zu Köln haben einen neuen Mechanismus entdeckt, der es ermöglicht, dass eine der aggressivsten Formen von Lungenkrebs der Behandlung entgeht, und eröffnet damit n ...

Small cell lung cancer (SCLC) is one of the most aggressive forms of lung cancer, with a five-year survival rate of only five percent. Despite this ...

Verhängnisvoller Mechanismus entdeckt: Kölner Wissenschaftler zeigen, wie sich aggressive Krebszellen tarnen – und warum das ...

A research team has now decoded the function of two key apoptotic genes from fish—Fas-associated protein with death domain ...

Small cell lung cancer (SCLC) is one of the most dangerous forms of lung cancer. It grows and spreads very quickly. Sadly, ...