DUBLIN--(BUSINESS WIRE)--Research and Markets has announced the addition of the "Calcium Pyruvate (CAS 52009-14-0) Global and Chinese Market Report - 2016" report to their offering. The 'Global and ...

Pyruvate kinase deficiency is a rare, hereditary, chronic condition that is associated with hemolytic anemia. In a phase 2 study, mitapivat, an oral, first-in-class activator of erythrocyte pyruvate ...

Proceedings of the National Academy of Sciences of the United States of America PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, ...

Despite the fact that most cancer cells display high glycolytic activity, cancer cells selectively express the less active M2 isoform of pyruvate kinase (PKM2). Here we demonstrate that PKM2 ...

Malaria that is caused by Plasmodium falciparum is a significant global health problem. Genetic characteristics of the host influence the severity of disease and the ultimate outcome of infection, and ...

Glucose is not only a major nutrient regulator of insulin secretion, but also impacts on gene expression in beta-cells. Using a mouse model of beta-cell-specific knock-out of Pdha1 gene which encodes ...

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a ...

Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of ...

The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase complex ...