T cells that are chronically stimulated in viral infection or cancer enter a dysfunctional state known as T-cell exhaustion. Sympathetic nerves in tissues and tumours drive T-cell exhaustion through ...
Beta3-adrenergic receptors (β3-AR) have emerged as pivotal modulators of cardiac performance, particularly in the context of heart failure. Distinct from the classical β1/β2-adrenergic signalling ...
Recent clinical studies have suggested that phenylacetylglutamine (PAGln), a novel gut microbial metabolite, can mechanistically modulate patients' risk of developing cardiovascular disease (CVD) and ...
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