A look at SNF computer and AI picks for this week's Sunday Night Football game between the Falcons and 49ers. Find Atlanta and San Francisco player props.

Kickoff from Levi's Stadium is set for 8:20 p.m. ET. San Francisco is a 1.5-point favorite in the latest Falcons vs. 49ers odds, and the over/under for total points scored is 47. Before making any 49ers vs. Falcons picks, be sure to see what the SportsLine projection model has to say .

The Atlanta Falcons' 2025 draft class has been among the most productive in the NFL through the first six weeks of the season. First-round picks Jalon Walker and James Pearce Jr. continue to make an impact despite being listed as second-string on the depth chart.

The Bills suffered a surprising loss to the New England Patriots 23-20 last Sunday as an 8-point favorite as the Under (48.5) cashed. The loss was Buffalo's first game this season in which it didn't hit at least 30 points. The AFC East keaders are led by QB Josh Allen, who has 1,217 passing yards and 12 total touchdowns.

The Atlanta Falcons take on the Buffalo Bills on Monday Night Football, and ESPN's weekly panel of analysts is unanimous in their pick of a winner.

Get the best Bills vs. Falcons predictions ahead of Monday's prime-time matchup in Atlanta. Free NFL picks for October 13.