Melanocortin-4 receptor (MC4R) is critical for energy homeostasis, and the paraventricular nucleus of the hypothalamus (PVN) is a key site of MC4R action. Most studies suggest that leptin regulates ...

The prevalence of obesity is steadily rising and has huge health and financial implications for society. Weight gain is due to an imbalance between dietary intake and energy expenditure and research ...

Gonadotropin-releasing hormone (GnRH) neurons exhibit many unique morphological features, including a blended dendrite–axon (dendron) that projects to the median eminence to secrete GnRH into the ...

In a new discovery, researchers from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences have identified a previously underexplored population of hypothalamic ...

Epigenetic events, such as methylation, during early brain development in mice occur in genomic regions associated with BMI in humans, according to a new study. Once it’s cleaved, the protein ...