In a recent study posted to the bioRxiv* pre-print server, researchers investigated allosteric binders of angiotensin-converting enzyme 2 (ACE2) that significantly inhibit severe acute respiratory ...

Allostery refers to the binding of a metabolite at a site other than the chemically active site of a protein. The existence of allosteric sites on receptor molecules has expanded potential drug ...

Drug hunters have spent years cutting chemical keys to fit the most obvious biological locks: a protein’s active site, the spot where its natural substrate clicks in to turn it on or off. Walk into ...

A novel compound strongly improves the efficacy of naloxone, the substance used to reverse overdoses of morphine, fentanyl and other opioid drugs. When administered to mice along with naloxone, it is ...