Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to ...

The study focuses on how immune cells react to amyloid-beta (Aβ) plaques, a hallmark of Alzheimer's, and how this immune response differs from the reaction to bacterial toxins. "Bacteria cannot ...

In mouse models, they found that the CSF Aβ42/40 ratio corresponded more closely to Aβ protofibrils in the brain than to plaques. In fact, statistical analyses determined that changes in the brain ...

Along with Aβ plaques, the second key pathology identified was neurofibrillary tangles (NFTs). Since the discovery of these two factors, our understanding of AD pathophysiology has continued to grow.

A comprehensive Thought Leaders Invited Review in Brain Medicine highlights the crucial role of CD2-associated protein (CD2AP ...

"Some hypothesized that microglia cleared amyloid-β (Aβ) plaques—the biological signature of Alzheimer's disease—from the brain, while others were convinced that microglia were involved in ...

The study focuses on how immune cells react to amyloid-beta (Aβ) plaques, a hallmark of Alzheimer's, and how this immune response differs from the reaction to bacterial toxins. “Bacteria cannot ...

A protein that impacts Alzheimer’s disease offers new opportunities for targeted treatments, although its cell-specific ...

Gene Hackman’s wife died of hantavirus, but could his own death be linked to infection? New research suggests infections may ...

The pathological hallmarks of Alzheimer's disease (AD) are amyloid-β (Aβ) plaques and Tau-containing neurofibrillary tangles. Although the relationship between neuronal loss and the presence of ...