Spatial transcriptomics on human brains parsed microglial reactions to amyloid immunotherapy. Both a vaccine and a therapeutic antibody summoned these cells to plaques. Responders expressed TREM2, ...

Alzheimer’s disease, a devastating neurodegenerative disorder, is closely linked to the accumulation of tau protein in the ...

The study focuses on how immune cells react to amyloid-beta (Aβ) plaques, a hallmark of Alzheimer's, and how this immune response differs from the reaction to bacterial toxins. "Bacteria cannot ...

Along with Aβ plaques, the second key pathology identified was neurofibrillary tangles (NFTs). Since the discovery of these two factors, our understanding of AD pathophysiology has continued to grow.

In mouse models, they found that the CSF Aβ42/40 ratio corresponded more closely to Aβ protofibrils in the brain than to plaques. In fact, statistical analyses determined that changes in the brain ...

The study focuses on how immune cells react to amyloid-beta (Aβ) plaques, a hallmark of Alzheimer's, and how this immune response differs from the reaction to bacterial toxins. “Bacteria cannot ...

Gene Hackman’s wife died of hantavirus, but could his own death be linked to infection? New research suggests infections may ...

The study focuses on how immune cells react to amyloid-beta (Aβ) plaques, a hallmark of Alzheimer's, and how this immune response differs from the reaction to bacterial toxins. "Bacteria cannot ...

Patients with advanced AD typically exhibit intracellular insoluble tau protein, forming neurofibrillary tangles (NFTs), alongside amyloid beta (Aβ) plaques in neurons. NFTs arise from tau ...