Le Sueur is a city in Le Sueur County in the U.S. state of Minnesota, between Mankato and the Twin Cities. It lies along the Minnesota Riv…Le Sueur is a city in Le Sueur County in the U.S. state of Minnesota, between Mankato and the Twin Cities. It lies along the Minnesota River and U.S. Highway 169. Le Sueur was named in honor of the French explorer Pierre-Charles Le Sueur. The population was 4,213 at the 2020 census.